Richard P. Hsung, now of the University of Wisconsin, has reported (Org. Lett. 2006, 8, 231. Formula of 2-Hexyloctanoic acid Methyl 6-chloro-5-formylpicolinate site DOI: 10.1021/ol052487s)the intramolecular addition of ynamides to…
Convergent coupling of a nucleophile with an aldehyde ideally will proceed with high enantioselectivity, while at the same time allowing the attachment of a usefully functionalized fragment. Several recently-reported aldehyde…
Powerful methods for the stereocontrolled construction of cyclic ethers have recently been developed, enabling the synthesis of a variety of complex natural products. Many of the Annonaceous acetogenins, represented by…
Heteroaromatics, including pyridines and indoles, play a prominent role in pharmaceutical chemistry. A new method for pyridine construction has recently been developed (Chem. Commun. 2006, 1313. DOI: 10.1039/b515901f) by Alexander…
There are several strategies now available for the catalytic enantioselective construction of oxygenated and aminated stereogenic centers. Catalytic processes for the enantioselective construction of alkylated stereogenic centers are just starting…
As new drug entities must be usually be prepared as single enantiomers, and as many contain one or more heterocyclic orcarbocyclic rings, there is an increased emphasis on the development…
Matthew J. Formula of 6-Bromo-2-oxaspiroheptane Pelc and Armen Zakarian from Florida State University have reported on the synthesis of A,G-spiroimine (1) of pinnatoxins (Tetrahedron Lett. 2006, 47, 7519. Sodium difluoromethanesulfinate…
The group of John A. Porco, Jr. and Scott E. Schaus from Boston University has reported on the synthesis of aryl ether C-glycoside derivatives 3 via Pd(0)-mediated allylic substitution of…
Two of the most common methods for homologating an aryl halide are the Heck reaction (1 -> 3) and the Suzuki reaction (4 -> 6). Shriniwas D. Samant of the…
Suzuki couplings using a microencapsulated palladium catalyst (Pd EnCat) under microwave heating were investigated by the group of Steven V. PMID:34856019 Ley at the University of Cambridge (Chem. 1450752-97-2 Purity…
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