Sharpless asymmetric epoxidation has long been a workhorse of enantioselective synthesis. The SAE protocol, however, gives only mediocre ee’s with cis allylic alcohols such as nerol (1). PMID:23381626 Hisashi Yamamoto…
Alcohols are the most common functional group protected, and benzyl is the most commonly used alcohol protecting group. Gregory B. Dudley of Florida State University has developed (J. Org. Chem.…
Last week (2006 Jan 23), aldol andMannich-based strategies for the catalytic enantioselective construction of extended arrays of aminated, oxygenated and alkylated stereogenic centers were reviewed. This week, the focus is…
The aza-Baylis-Hillman (aza-BH) reaction is a nucleophile-catalysed coupling of an imine with an electron-deficient olefin which provides direct access to highly functionalized chiral amines from readily available achiral starting materials.…
W. Edward Lendsell and Peter N. Preston of Herriot-Watt University, Edinburgh, have developed (Tetrahedron Lett. 2005, 46, 8695. DOI: 10.1016/j.tetlet.2005.10.038)a new family of Pd catalysts, exemplified by the complex 2.…
Strained three- and four-membered rings can be used to constructlarger rings. The release of the strain energy facilitates bond formation, and the stereochemistry of the small ring can be transmitted…
Chan-Mo Yu of Sungkyunkwan University, Suwon, has developed (Angew. Chem. Int. 3-Azidopropanoic acid uses Ed. 2006, 45, 1553. PMID:24580853 DOI: 10.1002/anie.200503863)a powerful strategy for assembling arrays of stereogenic centers, using…
Usually, aryl-aryl bonds are formed by the coupling of two functionalized aromatic carbons. Formula of Mesityl-λ3-iodanediyl diacetate Having both of the aromatic carbons functionalized is not always necessary. It is…
Alkenes are among the least expensive of organic functional groups. They are easily incorporated into a growing molecule, and are stable to many of the reagents that transform other functionality.…
Intramolecular carbene insertion (e.g. 1 -> 3) has long been a useful method for ring construction. Masahisa Nakada of Waseda University in Tokyo now reports (J. Am. Chem. Soc. Buy5-Methoxyquinazolin-4(3H)-one…
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