Kwihwan Park, Tsuyoshi Yamada, and Hironao Sajiki of Gifu Pharmaceutical University devised conditions for the exchange of the allylic alcohol 1 with D2O, to give the trideuterated allylic alcohol 2…
Burkhard König of University Regensburg observed significant diastereoselectivity in the conversion of the ketone 1 to the aldehyde 2 (Angew. Chem. Int. PMID:30125989 Ed. 2022, 61, e202211578. DOI: 10.1002/anie.202211578). John…
Acyclic stereoarrays are important both in themselves and as precursors to enantiomerically-defined ring systems. Although the aldol condensation has for many years been a workhorse for acyclic stereoselection, there are…
6,11-Epoxyisodaucane (3) was isolated from the liverwort Tritomaria polita. In the course of the synthesis of 3, a key step of which was the decyanative cyclization of the epoxide 1…
Rong-Jie Chein of the Academia Sinica, Taipei used the known (S)-(thiolan-2-yl) diphenylmethanol benzyl ether to catalyze the Johnson-Corey-Chaykovsky cyclopropanation of the enone 1 with the allylic bromide 2 to give…
eight(6814):86064. 42. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA (2003) Poor cell surface expression of human melanocortin4 receptor mutations related with obesity. J Biol Chem 278(25):229392945. 43. Windahl…
Ivation from shortterm latency. To confirm that fibroblasts had been productively infected, viral IE1 expression was validated by fluorescence microscopy (Fig. 1E). Similarly, lytic gene expression was observed when latently…
Elena V. PMID:32472497 5-Bromo-1,3-thiazole-2-carbaldehyde supplier Gusvskaya of the Universidade Federal de Minas Gerais and Matthias Beller of the Leibniz-Institut für Katalyse e.V. used benzaldehyde to convert the alcohol 1 to…
Shyam Sathyamoorthi of the University of Kansas showed that the epoxide 1 could be cyclized to the differentially-protected triol 2 (Org. Lett. 2022, 24, 939. DOI: 10.1021/acs.orglett.1c04310). David J. Aitken…
Qiao-qiao Teng and Ming Chen of Changzhou University showed that barium oxide is a strong enough base to doubly deuterate an alkyl nitrile 1, leading to 2 (Eur. J. 1196154-13-8…
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