The Li Synthesis of Paclitaxel (Taxol®)
Chemexpress Paclitaxel (Taxol®) (3) is a critical tool for cancer chemotherapy. PMID:27108903 Chuang-Chuang Li of the Southern University of Science and Technology developed a convergent approach to 3, based on the…
The Luo Synthesis of Grayanotoxin III
More than 25 grayanotoxin isoforms have been identified from rhododendron species, but grayanotoxin I and III are thought to be the principal toxic isoforms, leading to the well-known hazards of…
Which can raise the F0 parameter or lower the Fm parameter
Which can boost the F0 parameter or reduce the Fm parameter) or from an energetic uncoupling of the antenna from the reaction center. The latter phenomenon also leads to the…
Of p65 with inflammatory target genes as well as the release of inflammatory
Of p65 with inflammatory target genes and also the release of inflammatory cytokins. Hence, we infer that RCderived diterpenoid C is definitely an efficient inhibitor of NFB. In summary, RCderived…
The Carreira Synthesis of Euphorikanin A
Euphorikanin A (3), isolated from the roots of the Chinese succulent herb Euphorbia kansui, showed the ability to reactivate latent HIV. En route to 3, Erick M. PMID:25959043 Carreira of…
The Dong Synthesis of Phainanoid A
Phainanoid A (3), isolated from the shrub Phyllanthus hainanensis Merr., found only on Hainan Island, showed both promising toxicity against cancer cell lines, and immunosuppressive activity. Guangbin Dong of the…
The Rawal Synthesis of Heilonine
Helionine (3) was isolated from the Chinese lily Fritillaria ussuriensis, used in traditional medicine. Viresh H. Buy1,3,5-Tri(pyridin-4-yl)benzene Rawal of the University of Chicago devised a convergent approach to 3, based…
Ethylene-Alkyne Cross-Metathesis
Maurizio Botta and his group from the University of Siena, Italy have employed microwave mediated ethylene-alkyne cross-metathesis using Grubbs 2 catalyst for the synthesis of enantioenriched 2-substituted butadiens (Tetrahedron: Asymmetry…
C-H Functionalization: The Baran Synthesis of Maximiscine
Jie Wu of Taizhou University prepared the vinyl sulfone 3 by coupling the tertiary propargylic alcohol 1 with the diazonium salt 2 in the presence of sodium metabisulfite (Adv. Synth.…
Other Methods for Carbocyclic Construction: COTC (Buda), Brussonol (Jin/Qiu), Lingzhiol (Luo/Qin), Melicolone A (Martin), Macfarlandin C (Overman),
Mitrephorone A (Carreira) The crotonate ester COTC (3), an inhibitor of alkaline phosphodiesterase isolated from a soil Streptomyces, had cytotoxic and cancerostatic activity. Szymon Buda of Jagiellonian University prepared the…