Oxidation: The Zhu Synthesis of Cepharamine
Chemexpress Oleg V. Larionov of the University of Texas at San Antonio used an acridine photocatalyst to mediate the decarboxylative conversion of the carboxylic acid 1 to the sulfonamide 2 (Chem.…
Alkylated Stereocenters: The Fürstner Synthesis of Mycinolide IV
Pher G. Andersson of Stockholm University achieved high ee in the hydrogenation of the enone 1 to the ketone 2 (Org. 6-Bromo-2,3-dihydrobenzofuran manufacturer Fmoc-Phe(CF2PO3)-OH site Lett. PMID:23937941 2021, 23, 242.…
Heteroaromatics: The Okano Synthesis of Lamellarin Z
Christopher Uyeda of Purdue University reduced 1 to the intermediate vinylidene (also termed "alkylidene") carbene, that cyclized to the furan 2 (ACS Catal. 2021, 11, 193. DOI: 10.1021/acscatal.0c04713). Xinhao Zhang…
Reduction: The Dai Synthesis of Massarinolin A
Xiaobei Chen,Yanwei Hu and Shilei Zhang of Soochow University showed that the inexpensive calcium hydride could be used to reduce the aryl halide 1 to the arene 2 (Org. Chem.…
Diels-Alder Cycloaddition: Sinupol (Ota/Miyaoka), trans-α-Himachalene (Bach), Laurencenone C (List), Lamellodysidine A (Sugita), Kingianin A (Zhao/Chen/Lu), Sordaricin (Houk/Tang)
Sinupol (3), isolated from the soft coral Sinularia polydactyla, showed moderate inhibitory activity toward protein tyrosine phosphatase 1B. Koichiro Ota and Hiroaki Miyaoka of the Tokyo University of Pharmacy and…
Best Methods for C-C Bond Formation: Part Two of Three
Carbon-carbon bond formation is fundamental to all of organic chemistry. PMID:28440459 The emphasis this week is on recently-developed useful transformations that are easily scalable. Notably, these transformations telescope two or…
Alkylated Stereogenic Centers: The Ogawa Synthesis of Heliannuol E
Bruce H. Lipshutz of the University of California, Santa Barbara developed surfactants that allowed the aqueous enzymatic reduction of the enone 1 to the ketone 2 (Chem. Commun. 2021, 57,…
Rom 3 unique donors. (, p 0.05; , p 0.01).ing resulted within a considerable
Rom 3 distinct donors. (, p 0.05; , p 0.01).ing resulted in a substantial enhance in STAT1 protein levels in these cells (Fig. 3F). Paralleling STAT1 protein levels, levels of…
Bbreviated as (CP/C), revealed the differential expression of 329 genes involving
Bbreviated as (CP/C), revealed the differential expression of 329 genes amongst the two biofilms (see Tables two, S4 and S5). Comparison of gene expression upon selfcolonization (CC/C experiment) and upon…
Alkaloid Synthesis: Impatien A (Watson), cis-195J (Schneider), Galanthamine (Zhao), Stemoamide (Tang), Lythranidine (Sherburn), Aspidospermine (Liu)
Impatien A (3) was isolated from the Corydalis impatien, a flower of south China that is an important component in traditional Chinese medicine. Cyclopropanecarbaldehyde Order Donald A. Watson of the…