Alkene metathesis has become part of the toolkit of organic synthesis. PMID:24182988 Nevertheless, there is room for improvement in catalyst efficiency. 3-Isopropylpyridin-2(1H)-one web Robert H. Grubbs of the California Institute…
Gentle tapping of a terminal alkene specifically to the corresponding methyl-substituted internal alkene is a potentially value-adding transformation, as illustrated by the conversion of the inexpensive allylated ketone 1 to…
With the development of more advanced applications fororganocatalysts, several new approaches have been developed for the enantioselective construction of cyclopentanes. Karl A. Scheidt of Northwestern University has found (Angew. 2908-71-6…
Kou Hiroya of Tohoku University has described (Org. Lett. 2006,8, 5349. PMID:31085260 DOI: 10.1021/ol062249c)a versatile new route to pyrroles 2, based on the Pt-catalyzed rearrangement of azido alkynes such as…
Sugars are still useful chiral pool starting materials for the preparation of cyclic ethers. Jacquelyn Gervay-Hague of the University of California, Davis, has extended (Org Lett. 1047991-79-6 web 2006, 8,…
There are many ways Pd can be used to catalyze the substitution of an aryl halide. Jin-Heng Li of Hunan Normal University, Changsha, has found (J. Org. Chem. 2007, 72,…
Enantioselective addition to a prochiral ring is a powerful approach for the preparation of C-N rings in high ee. 458532-84-8 uses This is elegantly illustrated by the report (J. Org.…
Tohru Fukuyama of the University of Tokyo has recently reported (Org. Formula of Fmoc-α-Me-Gly(Pentynyl)-OH Lett. PMID:25429455 2006, 8, 5311. Price of 279236-77-0 DOI: 10.1021/ol062112m)an elegantly conceived total synthesis of (±)-morphine…
Retrosynthetic analysis of the heptacyclic ring structure of nominine (3), a representative member of the hetisine family of alkaloids, is not for the faint of heart. David Y. 334905-81-6 manufacturer…
Synthesis: Part One of Three We last reviewed organic synthesis applications of the Grubbs reaction on April 19, 2004. The (relatively) robust nature of the commercially-available catalyst and its commercial…
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