Stereoselective Construction of Carbocyclic Rings
Chemexpress Carbocyclic rings, unlike saturated heterocyclic rings, are not susceptible to the hepatic activation that is the basis of much drug toxicity. To pave the way for pharmaceutical discovery based on…
Metal-Mediated C-C Ring Construction: The Li Synthesis of Bufogargarizin A
Christopher Uyeda of Purdue University achieved high enantioselectivity in the cyclopropanation of myrcene (1) with 2,2-dichloropropane (2) to give 3 (J. Am. Chem. Soc. 2023, 145, 9441. DOI: 10.1021/jacs.3c01949). Qinglei…
Enantioselective Synthesis of Alcohols and Amines: The Zhang/Tu Synthesis of Eupomatilone-6
Vicente Gotor-Fernández and Iván Lavandera of the Universidad de Oviedo optimized the enzymatic reduction of the chloroketone 1 to the chlorohydrin 2, then telescoped that to begin with the 1-chloroalkyne…
C-N Ring Construction: The Louie Synthesis of Septicine
Malte Brasholz of the University of Rostock developed a protocol for the photochemically-driven in situ oxidation of the quinoxalinone 1 followed by cycloaddition with methacrylonitrile 2 to give the azetidine…
two.five L) and terminal TdT (25 Units) in buffer (Promega, Madison, WI). Cellspecific
two.five L) and terminal TdT (25 Units) in buffer (Promega, Madison, WI). Cellspecific immunohistochemical labeling was performed as previously described (Guyton et al. 2009). Briefly, before primary antibody staining, nonspecific…
The logistic regression analysis revealed that getting an injection drug user
The logistic regression evaluation revealed that being an injection drug user (IDU) was substantially related to HCV infection. Having said that, contrary to the majority of the existing literature, getting…
Substituted Benzenes: The Newhouse Synthesis of Shearilicine
Haibo Ge of Texas Tech University and Debabrata Maity of the Indian Institute of Technology Bombay effected the m-acetoxylation of the ester 1, leading to 2 (JACS Au 2023, 3,…
C-O Ring Construction: The Fuwa Synthesis of Exiguolide
Arjan W. Kleij of ICIQ optimized an aluminum catalyst for the conversion of the bis epoxide 1 to the oxetane 2 (ACS Catal. PMID:23399686 2022, 12, 5464. DOI: 10.1021/acscatal.2c00925). A.…
C-O Ring Construction: The Liu/Wang Synthesis of Miharimycin B
Mark G. 259214-55-6 uses McLaughlin of the University of Lancaster found that under alkaline conditions, the alcohol 1 could be cyclized to the iodo oxetane 2 (Chem. Commun. 2022, 58,…
The Barriault Synthesis of Ginkgolide C
The ginkgolides, in particular ginkgolide B, lacking the OH at C-7, are potent antagonists of platelet-aggregating acceptor (PAFR). PMID:24275718 Louis Barriault of the University of Ottawa described the first synthesis…