(+)-Subincanadine F (Li), (±)-Strychnine (Reissig), (-)-Virginiamycin M2 (Panek) Aldehydes such as 1 are readily available by direct enantioselective chlorination. Robert Britton of Simon Fraser University found (Org. Lett. 2010, 12,…
Adriaan J. Minnaard and Ben L. Feringa of the University of Groningen devised (J. Azido-PEG2-CH2COOH Price Am. Chem. Soc. 2010, 132, 14349. DOI: 10.1021/ja105704m) what promises to be a general…
Asymmetric epoxidation of a prochiral alkene is an appealing process because two stereogenic centers are established in the course of the reaction. Often, the starting alkene is inexpensive. 1203499-17-5 Order…
The complex polycyclic structure of N-Methylwelwitindolinone D Isonitrile (3) was assigned in 1999. The welwitinines show an intriguing range of biological activity, including reversal of P-glycoprotein-mediated multidrug resistance in human…
The Hajos-Parrish cyclization was a landmark in the asymmetric construction of polycarbocyclic natural products. PMID:24220671 Impressive at the time, the proline-mediated intramolecular aldol condensation proceeded with an ee that was…
The periwinkle-derived alkaloids vinblastine (2a) and vincristine (2b) are still mainstays of cancer chemotherapy. The more complex half of these dimeric alkaloids, vindoline (1), presents a formidable challenge for total…
Nt bone marrow-derived cells inside the development of atherosclerosis within this model . In contrast, transplantation of bone marrow from Tlr42/2 mice into Ldlr2/2 recipients, followed by feeding a high-cholesterol,…
Nhibitor II (40 nM); or MAPK inhibitor PD98059 (50 lM) for 1 hour at 378C. HCEC chemotaxis was measured in response to the buffer control (0.1 BSA in Gey’s buffer);…
Maoecrystal V (3), isolated from the Chinese medicinal herb Isodon eriocalyx, shows selective inhibition of HeLa cells at low nanomolar concentration (IC50 = 60 nm). 6-(Diphenylphosphino)-2,2′-bipyridine In stock Chuang-Chuang Li…
(-)-Actinophyllic Acid (3), isolated from Alstonia actinophylla, is a promising inhibitor of TAFIa/hippicuricase (0.84 µm). Larry E. Overman of UC Irvine envisioned (J. Am. Chem. 4-Aminomethylbenzylalcohol Price Soc. 2010, 132,…
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