Reduction: The Ogawa Synthesis of Maresin 2
Chemexpress Zheng Huang of the Shanghai Institute of Organic Chemistry showed that with an Ir catalyst, ethanol could serve as a reducing medium for the conversion of the alkyne 1 to…
Organocatalyzed C-C Ring Construction: The Gleason Synthesis of 3-Oxoisotaxodione
Hai-Chao Xu of Xiamen University used a phenothiazine-based catalyst to mediate the oxidative cyclization of the amide 1 to the cyclopropane 2 (J. Am. Chem. Soc. 2022, 144, 2343. DOI:…
Functional Group Interconversion: The Wang Synthesis of Spirojatamol
Daniele Leonori, now at RWTH Aachen University, employed visible light to promote the Co-catalyzed elimination of the primary bromide 1 to the alkene 2 (J. 2091009-80-0 site Am. PMID:24211511 Chem.…
Arrays of Stereogenic Centers: The Kalesse Synthesis of Chondrochloren A
Massimo Bietti of the Università "Tor Vergata" and Miquel Costas of the Universtat de Girona achieved substantial diastereoselectivity in the oxidative cyclization of the carboxylic acid 1 to the lactone…
Other Methods for C-C Ring Construction: Melicodenine C(Swierk/Brown), Myrioneurinol (Ma), Pleuromutilin (Pronin), Isorosthin L (Liang), Merrilactone A (Shenvi), Resiniferatoxin (Inoue)
Melicodenine C (4) was isolated from the leaves of Melicope denhamii, a rutaceous shrub found in Borneo that has been used in indigenous medicine. PMID:23892407 John R. Swierk of Binghamton…
Functional Group Protection: The Lee Synthesis of Jujuyane
A. PMID:28739548 Fmoc-Phe-OH Chemscene Venkat Narsaiah of CSIR-Indian Institute of Technology, Hyderabad selectively removed one of the silyl ethers of 1, to give 2 (Tetrahedron Lett. 2021, 82, 153410. DOI:…
Arrays of Stereogenic Centers: The Aisa Synthesis of Guaipyridine
Alois Fürstner of the Max-Planck-Institut für Kohlenforschung set the relative and absolute configuration of 3 by the Ni-mediated addition of the enol ether 2 to the aldehyde 1 (J. Am.…
Delicato Dipartimento di Scienze e Tecnologie Biologiche, ` Chimiche, Farmaceutiche, Universita di
Delicato Dipartimento di Scienze e Tecnologie Biologiche, ` Chimiche, Farmaceutiche, Universita di Palermo, Parco Orleans II, Ed. 17, 1690128 Palermo, Italy e mail: [email protected] R. Indelicato S. Barreca ` Dipartimento…
Y by elevated apoptosis within a Rho/Rhoassociated kinase (ROCK)dependent
Y by improved apoptosis within a Rho/Rhoassociated kinase (ROCK)dependent mechanism. Moreover, LPA inhibited the neuronal differentiation of iPSCs. Lastly, LPA induced neurite retraction of NS/ PCderived early neurons via Rho/ROCK,…
C-H Functionalization: The Davies/Sorensen Synthesis of Aflatoxin B2
Shouyun Yu of Nanjing University devised a protocol for the distal dehydrogenation of the acyloxyamide 1 to the alkene 2 (Org. Lett. 2021, 23, 6931. DOI: 10.1021/acs.orglett.1c02509). Armido Studer of…