Heteroaromatics: The Cho Synthesis of Decursivine
Chemexpress Marie-Isabelle Lannou and Geoffroy Sorin of the Université de Paris used Ag2O to cyclize the alkyne 1 to the furan 2 (Chem. Commun. 2022, 58, 1374. DOI: 10.1039/D1CC06379K). Rishikesh Narayan…
C-N Ring Construction: The Karimov Synthesis of a Nuphar Alkaloid
Weidi Cao and Xiaoming Feng of Sichuan University achieved high enantioselectivity in the ring expansion of the racemic aziridine with the isonitrile 2 to give the azetidine 3 (Org. Lett.…
Organocatalyzed C-C Ring Construction: The Sattely Synthesis of Momilactone
Arnaud Voituriez of the Université Paris-Saclay used a cyclic phosphine to mediate the assembly of the cyclobutene 3 by the addition of the β-diketone 1 to the acetylene dicarboxylate 2…
C-O Ring Construction: Triciadolide C (Wang), Nesteretal A (Ito), Toxicodenane (Han), Dehydro-exo-Brevicomin (Kanomata), Diocollettines A (Houk/Smith), Heliannuol K (Green)
The maleic anhydride derivative triciadolide C (3) was isolated from the aquatic hyphomycete Tricladium castaneicola. PMID:23460641 Shaozhong Wang of Nanjing University developed a general route to such anhydrides, exemplified by…
Functional Group Protection: The Murai/Arisawa Synthesis of Ansellone A
John C. Jewett of the University of Arizona demonstrated that the protected diazonium salt 1 participated efficiently in Suzuki coupling, leading the biphenyl 2 (Org. Lett. 2021, 23, 1851. DOI:…
Post. This study confirmed the protective effect of butorphanol postC on
Post. This study confirmed the protective impact of butorphanol postC on ischaemic myocardium in reperfusion injury. We used 50 g kg1 of butorphanol primarily based on our earlier report that…
The cells had been transfected with TRPC3 siRNA as described above and
The cells have been transfected with TRPC3 siRNA as described above and starved overnight before incubation with FSH for an added 48 hr. Cisplatin was added at a final concentration…
Enantioselective Synthesis of Alcohols and Amines: The Yang Synthesis of Colchicine
Guosheng Liu of the Shanghai Institute of Organic Chemistry devised the enantioselective Pd-catalyzed diacetoxylation of the alkene 1 to the bis-acetate 2 (Nature Catal. 2021, 4, 172. DOI: 10.1038/s41929-021-00574-5). Bingxian…
Diastereoselective and Enantioselective Construction of Cyclic Ethers
Because the stereocontrolled construction of cyclic ethers has been difficult and expensive, the use of cyclic ethers as pharmaceuticals has not been fully explored. 1,2,3,4-Tetrahydrobenzoquinoline Chemical name With the development…
Substituted Benzenes: The Yang/Zhang Synthesis of Cephanolide B
Duen-Ren Hou of the National Central University devised a simple protocol for the direct acetoxylation of the substituted benzene 1, leading to the aryl acetate 2 (Org. Lett. 2021, 23,…