(-)-Podophyllotoxin 1 and its derivative etoposide 2, derived from natural sources, are in current clinical use. Michael Sherburn of Australian National University reports (J. PMID:23618405 Am. 2-Methylpyrimidine-5-carbaldehyde custom synthesis Chem.…
Nt (Table S1 in the Supporting Information and facts). The omit density map shows a single Mn(II) ion (Mn1) within a tetrahedral coordination complex with three amino acid residues (Cys98,…
:10.1371/journal.pone.0079682.tPLOS 1 | www.plosone.orgHeritability of Uremic Retention MoleculesTable two. Baseline qualities by quartiles of pcresyl sulfate.PCresyl Sulfate, mmol/L Characteristics Qualities n ( ) Males Hypertension Antihypertensive drug intake Diabetes mellitus…
Kegong Ji of the Northwest Agricultural & Forestry University used a Cu catalyst to cyclize the alkyne 1 to the furan 2 (Org. 8-Hydroxyoctanoic acid In stock Chem. Front. 2023,…
Tabertinggine (4) was isolated from the Mayasian shrub Tabernaemontana corymbosa, the dwarf pinwheel. Xuegong She of Lanzhou University assembled the key tetracyclic intermediate 3 by the BINOL-derived phosphoric acid mediated…
Spiroapplanatumine O (3) was isolated from Ganoderma applantum, a wood-decaying fungus that is widely used in traditional medicinal chemistry. Ullrich Jahn of the Institute of Organic Chemistry and Biochemistry of…
Spirooliganone A (Morita), Microansamycin H (Sittihan), Gymnothelignan N (Lee), 3(11)-Epoxyhypoestenone (Wang/Chen) Ophiofuranone A (3) was isolated from the endolichenic fungus Ophiospaerella korrae. Rainer Schobert of the University Bayreuth prepared the…
John P. Price of 3-Chloro-1H-pyrazole Wolfe of the University of Michigan constructed the cyclobutene 3 by coupling the enol triflate 1 with diethyl malonate 2 (Org. Lett. 2022, 24, 8208.…
Masato Matsugi of Meijo University prepared the carbamoyl azide 2 by reaction of the hydroxamic acid 1 with diphenyl phosphorazidate (Tetrahedron Lett. PMID:32261617 2022, 95, 153727. DOI: 10.1016/j.tetlet.2022.153727). Yan Zhao…
Benjamin Darses of the Université Grenoble-Alpes and Marie Sircoglou and Philippe Dauban of the Université Paris-Saclay effected the enantioselective aziridination of the terminal alkene 1 with 2, leading to 3…
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