Borane Complexes in Organic Synthesis
Chemexpress The application of boron reagents in organic synthesis led to Herbert C. Brown (1912-2004) being awarded the Nobel Prize in Chemistry in 1979 (Angew. Chem. Int. Ed. PMID:23756629 BrettPhos Pd…
O-Heterocyclic Construction by Alkene Metathesis
In the preparation of enantiomerically-pure starting materials, it is not uncommon for the early low molecular weight intermediates to require special handling. Often, the initial stereogenic centers are derived from…
Best Methods for C-C Bond Formation: Part Three of Three
Carbon-carbon bond formation is fundamental to all of organic chemistry. 5-Fluoro-2-hydroxybenzonitrile Formula The emphasis again this week is on practical, scalable methods. Formylation of organometallics is usually carried out with…
Synthesis of Heterocyclic Natural Products: (-)-Ephedradine A, (-)-α-Tocopherol, (-)-Lepadin D and (-)-Phenserine
Stereocontrolled syntheses of macrolides and macrolactams are well developed. PMID:28038441 1220019-95-3 In stock Much remains to be done toward the efficient enantioselective construction of five and six-membered cyclic ethers and…
T or chiA/chiALF82 infected HEK293 cells 24 hours post infection, as
T or chiA/chiALF82 infected HEK293 cells 24 hours post infection, as in comparison to that from uninfected cells . In contrast, the remaining mutant strains (LF82chiA, chiA/chiAK12, chiA/chiALF825MU or 52D11)…
Er amounts. In summary, the aforementioned outcomes reveal that the metalcatalyzed
Er amounts. In summary, the aforementioned results reveal that the metalcatalyzed and the organocatalytic procedures have a different behavior depending upon the substitution pattern. Hence, whereas the metalcatalyzed process afforded…
Stereocontrolled Construction of Cyclic Ethers
While N-heterocycles have dominated pharmaceutical synthesis from its inception, the increasing facility with which complexcyclic ethers can be assembled suggests that such cyclic ethers could also be suitable pharmaceutical platforms.…
Enantioselective Ring Construction by Intramolecular C-H Insertion and by Cycloaddition
The prochiral aziridine 1 is easily prepared from cyclooctene. Paul Müller of the University of Geneva has shown (Helv. Chim. Buy362522-50-7 Acta 2004, 87, 227. DOI: 10.1002/hlca.200490010)that metalation of 1…
Oxidation: The Frantz Route to Artemisinin
Imre Pápai and Tibor Soós of the Institute of Organic Chemistry, Budapest prepared the oxetane 3 by the relay ring-closing methathesis of the alkene 1 with the diene 2 (Angew.…
Arrays of Stereogenic Centers: The Wei/Yang Synthesis of Cephalotaxine
Joshua D. Sieber of Virginia Commonwealth University used a Cu catalyst to mediate the assembly of the protected amino alcohol 3 by the addition of the allenamide 2 to the…