Enantioselective Ring Construction: Part One of Two
Chemexpress As new drug entities must be usually be prepared as single enantiomers, and as many contain one or more heterocyclic orcarbocyclic rings, there is an increased emphasis on the development…
Scaffold Decoration of C-Glycosides
The group of John A. Porco, Jr. and Scott E. Schaus from Boston University has reported on the synthesis of aryl ether C-glycoside derivatives 3 via Pd(0)-mediated allylic substitution of…
Tandem Claisen-Mislow-Evans Rearrangement
Matthew J. Formula of 6-Bromo-2-oxaspiroheptane Pelc and Armen Zakarian from Florida State University have reported on the synthesis of A,G-spiroimine (1) of pinnatoxins (Tetrahedron Lett. 2006, 47, 7519. Sodium difluoromethanesulfinate…
Preparation of Benzene Derivatives
Two of the most common methods for homologating an aryl halide are the Heck reaction (1 -> 3) and the Suzuki reaction (4 -> 6). Shriniwas D. Samant of the…
Asymmetric Mannich Reaction
Carsten Bolm and Belén Rodríguez from the University of Aachen investigated thermal effects in the (S)-proline-catalyzed Mannich reaction (J. Org. Chem. 2006, 71, 2888. (R)-2-Methylazetidine hydrochloride structure DOI: 10.1021/jo060064d). By…
Microwave-Assisted Suzuki Couplings with Simultaneous Cooling
Suzuki couplings using a microencapsulated palladium catalyst (Pd EnCat) under microwave heating were investigated by the group of Steven V. PMID:34856019 Ley at the University of Cambridge (Chem. 1450752-97-2 Purity…
Phosphine Gold(I)-Catalyzed Hydroamination of Alkenes
Chi-Ming Che and co-workers from the University of Hong Kong have reported on the intra- and intermolecular hydroamination of unactivated alkenes (Org. Lett. 2006, 8, ASAP. DOI: 10.1021/ol060719x). In a…
Synthesis of 7-Azaindoles
Hartmut Schirok from Bayer HealthCare, Germany, has reported on a short and flexible synthesis of 1,3-substituted 7-azaindoles 2 starting from oxiranes 1 (J. PMID:23724934 Org. Chem. 2006, 71, 5538.DOI: 10.1021/jo060512h).…
Ring Closing Metathesis for Guaianolide Synthesis
Oliver Reiser and his group from the University of Regensburg, Germany have reported on the ring-closing metathesis (RCM) of a sterically demanding substrate in the context of the total synthesis…
Single-Step Synthesis of Pyrimidine Derivatives
Mohammad Movassaghi and Matthew D. Hill from MIT have developed a protocol for the synthesis of quinazolines 1 via electrophilic activiation of secondary amides utilizing 2-chloropyridine (2-ClPyr) in combination with…