Synthesis of N-Heterocycles via Iminyl Radicals
Chemexpress John Walton and co-workers from the University of St. Andrews, UK, have reported on the use of O-phenyl oxime ethers as precursors for iminyl radicals en route for N-heterocycle synthesis…
Ru-Catalyzed Aryl Azide-Alkyne Cycloaddition
The synthesis of 1,2,3-triazoles via Ru-catalyzed aryl azide-alkyne cycloadditions was described by the group of Valery Fokin from The Scripps Research Institute (Org. Lett. 2007, 9, 5337. DOI: 10.1021/ol701912s). PMID:35991869…
Gold(I)-Catalyzed Intramolecular [4+2] Cycloadditions
The intramolecular cycloaddition of alkenyl- (1) and aryl-substitued 1,6-enynes 2 was described by the group of Antonio Echavarren from the Institute of Chemical Research of Catalonia (ICIQ), Spain, (J. PMID:25046520…
Ng the initiation of lesion development43. Therefore, it can not be excluded
Ng the initiation of lesion development43. For that reason, it can’t be excluded that ADAM8 may well have an impact at earlier developmental stages, since all atherosclerotic lesions in this…
Ine RegorafenibaHypertension (calcium channel) HIV (reverse transcriptase) HIV (reverse transcriptase) Hypertension
Ine RegorafenibaHypertension (calcium channel) HIV (reverse transcriptase) HIV (reverse transcriptase) Hypertension (calcium channel) Hypertension (calcium channel) Leukemia (tyrosine kinase) Thyroid cancer (tyrosine kinase) Prostate cancer (CYP17A1) Hypertension (angiotensin II receptor)…
Rh-Catalyzed Transannulation of 1,2,3-Triazoles
The groups of Vladimir Gevorgyan and Valery Fokin from the University of Illinios and The Scripps Research Institute have reported on the synthesis of imidazoles via the transannulation of 1-sulfonyl…
Transition Metal-mediated Ring Construction: The Yu Synthesis of 1-Desoxyhypnophilin
Both 1 and 3 are inexpensive prochiral starting materials. Tae-Jong Kim of Kyungpook National University devised (Organomet. 2008, 27, 1026.DOI: 10.1021/om700935m) a chiral Cu catalyst that efficiently converted 1 (other…
Enantioselective Arylation of Aromatic Aldehydes
The groups of Antonio Braga und Ludger Wessjohann from Universidade Federal de Santa Maria, Brazil, and the Leibniz Institute of Plant Biochemistry, Germany, have reported on the arylation of aromatic…
Synthesis of 2-Arylindoles via Tandem Radical Cylization
The synthesis of 2-arylindoles 3 via tandem radical cyclization of the corresponding acrylates 1 and subsequent oxidation was reported by the group of Oliver Reiser from the Universtiy of Regensburg,…
Synthesis of Substituted Benzenes: The Carter Synthesis of Siamenol
Tosylates are among the least expensive, but also among the least reactive toward Pd(0) oxidative addition, of aryl sulfonates. Jie Wu of Fudan University has now devised conditions (J. Org.…