The power of catalytic C-H functionalization is illustrated by the elegant synthesis of rhazinicine (3) devised (Angew. Chem. PMID:34235739 Int. Ed. 2008, 47, 3004. DOI: 10.1002/anie.200705005)by Matthew J. Propargyl-PEG1-NHS ester…
Peter Legzdins of the University of British Columbia has described (J. Formula of 273930-54-4 Am. Chem. Soc. 2007, 129, 5372.DOI: 10.1021/ja0713633)a stoichiometric tungsten complex that specifically functionalized the primary H…
Jon D. Rainier of the University of Utah has put forward (J. Am. Chem. Soc. 2007, 129, 12604. DOI: 10.1021/ja073880r)an elegant alternative to Ru-catalyzed alkene metathesis, demonstrating that an ω-alkenyl…
Benjamin List of the Max Planck Institute, Mülheim devised (J. PMID:24293312 Am. Chem. Soc. 2008, 130, 6070.DOI: 10.1021/ja801181u)a chiral primary amine salt that catalyzed the enantioselectiveepoxidation of cyclohexenone 1. Larger…
Yasutaka Ishii of Kansai University has developed (J. Org. PMID:24982871 Chem. 2007, 72, 8820. DOI: 10.1021/jo701635f)a novel route to furans, using a mixed-metal catalyst to effect condensation of an aldehyde…
Several new developments in enantioselective C-O ring construction have been applied in the syntheses of natural products. Buy3-(Hydroxymethyl)pyrrolidin-2-one To achieve control, the oxygenated quaternary center of dysiherbaine (9) must be…
Alkene metathesis has been extended to increasingly complex starting materials and products. Nitriles are good donors to coordinatively-unsaturated transition metal centers, so tend to inhibit the reaction. PMID:35345980 Ren He…
Usually, only a single enantiomer of a pharmaceutical is the useful drug. Often, the synthesis of the single enantiomer depends on the ability to form C-O or C-N bonds with…
Jeffrey C. Pelletier of Wyeth Research, Collegeville, PA has developed (Tetrahedron Lett. 2007, 48, 7745. DOI: 10.1016/j.tetlet.2007.09.034)a easy work-up Mitsunobu procedure for the conversion of a primary alcohol such as…
Several new routes to furans and to pyrroles have recently been put forward. Inspired by the Achmatowicz ring expansion, Patrick J. Walsh of the University of Pennsylvania developed (J. Am.…
Chemexpress