Stereocontrolled C-O Ring Construction
Chemexpress Sugars are still useful chiral pool starting materials for the preparation of cyclic ethers. Jacquelyn Gervay-Hague of the University of California, Davis, has extended (Org Lett. 1047991-79-6 web 2006, 8,…
Enantioselective Synthesis of C-N Ring Containing Natural Products
Enantioselective addition to a prochiral ring is a powerful approach for the preparation of C-N rings in high ee. 458532-84-8 uses This is elegantly illustrated by the report (J. Org.…
The Gin Synthesis of Nominine
Retrosynthetic analysis of the heptacyclic ring structure of nominine (3), a representative member of the hetisine family of alkaloids, is not for the faint of heart. David Y. 334905-81-6 manufacturer…
The Fukuyama Synthesis of Morphine
Tohru Fukuyama of the University of Tokyo has recently reported (Org. Formula of Fmoc-α-Me-Gly(Pentynyl)-OH Lett. PMID:25429455 2006, 8, 5311. Price of 279236-77-0 DOI: 10.1021/ol062112m)an elegantly conceived total synthesis of (±)-morphine…
The Grubbs Reaction in Organic
Synthesis: Part One of Three We last reviewed organic synthesis applications of the Grubbs reaction on April 19, 2004. The (relatively) robust nature of the commercially-available catalyst and its commercial…
The Sorensen Synthesis of (-)-Guanacastepene E
The guanacastepenes, of which guanacastepene E (3) is representative, initially elicited excitement because of their activity against drug resistant bacterial strains. Although the systemic toxicity of the guanacastepenes has cooled…
The Trost Synthesis of (-)-Terpestacin
(-)-Terpestacin (3), isolated from Arthrinium sp. Buy157327-48-5 FA1744, inhibits the formation of syncytia by HIV-infected T cells. PMID:26644518 A key step in the total synthesis of 3 reported (J. Buy2-Chloro-5,7-difluorobenzothiazole…
The Crimmins Synthesis of (+)-SCH 351448
The symmetrical macrodiolide (+)-SCH 351448 (4) is the only known selective activator of transcription from the low density lipoprotein receptor. The highly convergent synthesis of 4 from 1 and 2…
The Overman Synthesis of (-)-Sarain A
Larry E. Overman of the University of California, Irvine has recently (Angew. Chem. Int. PMID:25959043 2,4-Bis(trifluoromethyl)benzaldehyde supplier Ed. 2006, 45, 2912. DOI: 10.1002/anie.200600417)described the first total synthesis of the antibiotic…
The Clark Synthesis of Vigulariol
Vigulariol (3), isolated from the octocoral Vigularia juncea (Pallas), is active against human lung adenocarcinoma cells (IC50 = 18 nM). A key step in the synthesis of 3 reported (Angew.…