Selective C-H Functionalization
Chemexpress Direct conversion of an unactivated C-H bond to a C-O, C-N or C-C bond is a powerful way to add valuable complexity to a substrate. While this is by no…
Pushing the Limits of Alkene Metathesis in Natural Product Synthesis
While alkene metathesis has become part of the toolkit of organic synthesis, investigators around the world are pushing the limits of the method as they employ the reaction in total…
Transition Metal-Mediated Synthesis of Carbocycles: The Snapper Synthesis of Pleocarpenone
Several creative new approaches to carbocyclic ring construction using transition metals have recently been reported. Dichlorocyclopropanes such as 1 are easily prepared by the addition of dichlorocarbene to the corresponding…
Suzuki Cross Couplings for Oligothiophene Synthesis
A recent publication by G. Barbarella and co-workers from Bologna, Italy (J. Org. Chem. 2004, 69, 4821.DOI: 10.1021/jo035723q)reports the rapid preparation of poorly soluble unsubstituted and modified α-quinque and sexithiophenes…
Enantioselective Construction of Alcohols and Amines
Thomas Lectka of Johns Hopkins University has reported (J. PMID:24487575 Am. Chem. Soc. 2006, 128, 1810. DOI: 10.1021/ja058077g)an elegant method for the enantioselectiveα-hydroxylation of carboxylic acids. Chiral amine catalyzed condensation…
Ontaining 1 m: of 25 mM HEPES (pH 7.five), 0.three M sucrose, 10 mM CaCl2, 10 mM
Ontaining 1 m: of 25 mM HEPES (pH 7.five), 0.three M sucrose, 10 mM CaCl2, ten mM MgCl2. Fresh Arabidopsis rosette leaves had been harvested from 4-week-old plants grown in…
N open access post below the CC BY-NC-ND license (http://creativecommons.
N open access short article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). www.molecularmetabolism.comThese outcomes confirmed that NNT is essential for the effects of glucose and FCCP on islet NADPH. On the…
Quinoxaline Synthesis via an Ugi-Smiles Sequence
The groups of Laurent El Kaïm and Laurence Grimaud from Ecole Nationale Supérieure de Techniques Avancées in Paris have reported on the generation of quinoxaline scaffolds (Heterocycles 2007, 73, ASAP.…
Stereocontrolled Natural Product Synthesis: Cyclic Ethers and Macrolides
Duncan J. Wardrop of the University of Illinois, Chicago, established (Org. 529476-80-0 Chemical name Lett. 2006, 8, 3659.DOI: 10.1021/ol0609053)the five-membered ether ring of (±)-magnofargesin (3) by the addition of benzenesulfinate…
Cascade Reactions in the Total Synthesis of Artochamins F, H, I and J
K. C. Nicolaou and his group from the Scripps Research Institute have performed the total synthesis of artochamins F and H-J applying microwave heating for the key step (Angew. Chem.…