(-)-Kainic Acid (Tomooka), Dasycarpidone (Bennasar), (-)-Cephalotaxine (Ishibashi) and Lysergic Acid (Fujii/Ohno) Intriguing strategies have been developed for the stereocontrolled assembly of complex alkaloid structures. Brian M. Stoltz of Caltech prepared…
One of the most practical ways to construct enantiomerically-enriched carbocyclic systems is to effect asymmetric transformation of preformed prochiral rings. Choon-Hong Tan of the National University of Singapore observed (Chem.…
(+)-Omaezakianol Tobin J. Marks of Northwestern University observed (J. Am. Chem. Soc. 2009, 131, 263. DOI: 10.1021/ja8072462) high geometric control in the cyclization of 1 to 2. Tristan H. Lambert…
The Sharpless osmium-catalyzed asymmetric dihydroxylation is widely used. Lawrence Que, Jr. of the University of Minnesota designed(Angew. Chem. Int. Ed. 2008, 47, 1887DOI: 10.1002/anie.200705061)a catalyst with the inexpensive Fe that…
E PD. Evidence that siRNAs function as guides, not primers, from the Drosophila and human RNAi pathways. Mol Cell. 2002;ten:537?8. Thomson DW, Bracken CP, Goodall GJ. Experimental strategies for microRNA…
At both the H53A and H53D mutants showed dTMP formation with dramatically decreased activity (Table S2 of reference 17).Benefits and DiscussionWe have crystallized and solved the structures of H53D mutant…
Products such as 3 and 6 are usually prepared by phosphonate condensation. J. S. PMID:23756629 Yadav of the Indian Institute of Technology, Hyderabad found (Tetrahedron Lett. 2008, 49, 4498. DOI:…
B (de la Pradilla), Sanguiin H-5 (Spring), Solandelactone A (White), Spirastrellolide A (Paterson) Richard J. K. Taylor of the University of York has developed (Angew. Buy2422999-74-2 Chem. Int. Ed. PMID:23892407…
(-)-Ushikolide A (4), isolated from a culture broth of Streptomyces sp. IUK-102, showed powerful activity against murine splenic lymphocyte proliferation (IC50 = 70 nM). The most important player in the…
The total synthesis of Epothilone B (4), the first natural product (with Epothilone A) to show the same microtubule-stabilizing activity as paclitaxel (Taxol®), has attracted a great deal of attention…
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