Ming Yan of Sun Yat-sen University, Guangzhou, optimized (Synlett 2010, 266. DOI: 10.1055/s-0029-1218570) the organocatalyzed addition of 2 to a cyclic enone 1, establishing the cyclopropane 3 with high diastereo-…
SC-Δ13-9-IsoF (Taber), Brevisamide (Panek, Lindsley, Ghosh), Gambierol (Mori) The challenge of controlling the relative and absolute configuration of highly substituted cyclic ether-containing natural products continues to stimulate the development of…
Xiang-Ping Hu and Zhuo Zheng of the Dalian Institute of Chemical Physics developed (Org. Lett. 2009, 11, 3226, DOI: 10.1021/ol9012469; J. Org. Chem. 2009, 74, 9191, DOI: 10.1021/jo901619c) a family…
Huanfeng Jiang of the South China University of Technology showed (J. Org. 5-Bromo-2-(tert-butyl)pyridine Purity Chem. 2010, 75, 966. DOI: 10.1021/jo902375k) that an alkynoate 1 could be condensed with a 1,3-dicarbonyl…
Lee), (-)-Amphidinolide K (Eun Lee), Norhalichondrin B (Phillips) A variety of antibiotics and immune-suppressive agents contain extended arrays of all-(E)-polyenes. Samir Bouzbouz of CNS Rouen and Janine Cossy of ESPCI…
Ng oestrogen and progesterone receptors and HER-2 gene amplification, account for ten?0 of all breast carcinomas in Asian and Western populations (Thike et al, 2010; De Ruijter et al, 2011).…
For synthesis of higher polyamines, putrescine controls the self-processing conversion of SAM decarboxylase (AMD1) proenzyme for the active enzyme (Pegg, 2009). Moreover, putrescine can bind an allosteric site in AMD1…
Vinyl glycine 2 is a useful precursor to a variety of amino acids. PMID:23789847 Timothy E. Long of the University of Georgia found (Tetrahedron Lett. 2009, 50, 5067. DOI: 10.1016/j.tetlet.2009.06.082)…
(+)-Rotundial Karl Anker Jørgensen of Aarhus University found (Angew. Chem. Int. 1075198-30-9 Formula Ed. 2009, 48, 6650. DOI: 10.1002/ange.200903253) that an organocatalyst could mediate the fragmentation of the prochiral cyclopropane…
Masato Kitamura of Nagoya University investigated (Chem. Lett. 2009, 38, 188. DOI: 10.1246/cl.2009.188) the Ru-mediated deprotection of allyl ethers such as 1. The same catalyst was effective for the preparation…
Chemexpress