The complex polycyclic structure of N-Methylwelwitindolinone D Isonitrile (3) was assigned in 1999. The welwitinines show an intriguing range of biological activity, including reversal of P-glycoprotein-mediated multidrug resistance in human…
The periwinkle-derived alkaloids vinblastine (2a) and vincristine (2b) are still mainstays of cancer chemotherapy. The more complex half of these dimeric alkaloids, vindoline (1), presents a formidable challenge for total…
The Hajos-Parrish cyclization was a landmark in the asymmetric construction of polycarbocyclic natural products. PMID:24220671 Impressive at the time, the proline-mediated intramolecular aldol condensation proceeded with an ee that was…
Nt bone marrow-derived cells inside the development of atherosclerosis within this model . In contrast, transplantation of bone marrow from Tlr42/2 mice into Ldlr2/2 recipients, followed by feeding a high-cholesterol,…
Nhibitor II (40 nM); or MAPK inhibitor PD98059 (50 lM) for 1 hour at 378C. HCEC chemotaxis was measured in response to the buffer control (0.1 BSA in Gey’s buffer);…
Maoecrystal V (3), isolated from the Chinese medicinal herb Isodon eriocalyx, shows selective inhibition of HeLa cells at low nanomolar concentration (IC50 = 60 nm). 6-(Diphenylphosphino)-2,2′-bipyridine In stock Chuang-Chuang Li…
(-)-Actinophyllic Acid (3), isolated from Alstonia actinophylla, is a promising inhibitor of TAFIa/hippicuricase (0.84 µm). Larry E. Overman of UC Irvine envisioned (J. Am. Chem. 4-Aminomethylbenzylalcohol Price Soc. 2010, 132,…
The Z alkene of Nakadomarin A (3) suggested to Raymond L. Funk an approach (Org. Lett. 2010, 12, 4912. DOI: 10.1021/ol102079z) based on ring-closing alkyne metathesis. The efficient assembly of…
The pentacyclic Apocynaceae alkaloid Aspidophylline A (3) was shown to reverse drug resistance in resistant KB cells. In developing a strategy for the assembly of 3, Neil K. PMID:25804060 Garg…
An investigation of the activity of the Galbulimima alkaloids, exemplified by (-)-GB 13, led to the development of a series of potent thrombin receptor antagonists. Buy138099-40-8 Dawei Ma of the…
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