Enantioselective hydrogenation of enamides is a well-established transformation. The corresponding reduction of enamines has been elusive. Qi-Lin Zhou of Nankai University designed (J. Am. Chem. Soc. 2009, 131, 1366. DOI:…
Ed myocardium with the spontaneously hypertensive rats (SHR), there was an increased activation of NHE1 and NHE1 inhibition lowered cardiac hypertrophy and interstitial fibrosis . Transgenic mice expressing activated NHE1…
Nce of LDL(-) inside the LDL fraction of Ldlr-/- mice was confirmed by physical chemical and antigenic characteristics. Macrophage viability. The MTT assay showed that cell viability was not impacted…
Fabio Doctorovich of the Universidad de Buenos Aires reported(J. Org. 201929-84-2 Chemscene Chem. 2008, 73, 5379DOI: 10.1021/jo800302v)that hydroxylamine in the presence of an Fe catalyst reduced alkenes such as 1,but…
Arumugam Sudalai of the National Chemical Laboratory, Pune reported(Tetrahedron Lett. 2008, 49, 6401.DOI: 10.1016/j.tetlet.2008.08.071)a procedure for hydrocarbon iodination. With straight chain hydrocarbons, only secondary iodination was observed. 227454-58-2 site Chao-Jun…
Several new methods for the direct functionalization of Ar-H have appeared. PMID:24377291 Hisao Yoshida of Nagoya University observed (Chem. Comm. 2008, 4634. DOI: 10.1039/b811555a) that under irradiation, TiO2 in water…
A Tanmaya Pathak of the Indian Institute of Technology, Kharagpur devised (J. Org. Price of 6-Chloro-3-fluoro-2-methoxypyridine Chem. NH2-PEG2-C2-Boc structure 2009, 74, 2710. DOI: 10.1021/jo802709q) a preparation of enantiomerically-pure oxygenated cyclopropanes…
Carsten Bolm of RWTH Aachen developed (Angew. Chem. Int. Ed. 2008, 47, 8920 DOI: 10.1002/anie.200803709) an Ir catalyst that effected hydrogenation of trisubstituted enones such as 1 with high ee.…
Alkene metathesis (e.g. 1 + 2 -> 3) has been known at least since the 1950’s. Until Robert Grubbs of Caltech developed stable and versatile Ru catalysts for this transformation,…
Chaozhong Li of the Shanghai Institute of Organic Chemistry demonstrated (Org. Lett. 2008, 10, 4037 DOI: 10.1021/ol801545a) facile and selective Cu-catalyzed β-lactam formation, converting 1 to 2. Paul Helquist of…
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