Reactions of Alkenes
Chemexpress Ana C. Fernandes of the Instituto Superior Técnico, Lisboa, devised (Tetrahedron Lett. 2010, 51, 1048. DOI: 10.1016/j.tetlet.2009.12.061) an effective Re catalyst for the solvent-free hydrogenation of an alkene 1. Yasushi…
Enantioselective C-C Bond Construction: Part Two of Three
Stilbene diols such as 3 are gaining prominence both as synthetic intermediates and as effective chiral auxiliaries. While the diols can be prepared in high ee by Sharpless dihydroxylation, it…
Centration-dependent manner (Figure 3D, appropriate) that peaked 24 hours after the get started
Centration-dependent manner (Figure 3D, ideal) that peaked 24 hours immediately after the commence of treatment.5-FU Effects on Pim-1 Expression Are Mediated by miR-15bTo address the 5-FU ediated up-regulation of Pim-1…
Stereocontrolled Construction of Arrays of Stereogenic Centers: The Mullins
Synthesis of (-)-Lasiol Hisashi Yamamoto of the University of Chicago devised (J. Am. Chem. Soc. 2010, 132, 7878. DOI: 10.1021/ja100951u) catalyst systems for the enantioselective epoxidation of a Z-homoallylic alcohol…
Organic Functional Group Protection
We found (Tetrahedron Lett. PMID:36014399 2010, 51, 3545. DOI: 10.1016/j.tetlet.2010.04.129) that the superiority of KH over NaH in the Williamson ether synthesis was particularly marked with congested partners such as…
Substituted Benzenes: The Kirsch Synthesis of Cybrodol
Stephen L. Buchwald of MIT established (J. Am. Buy885588-14-7 Chem. Soc. 2010, 132, 14076. DOI: 10.1021/ja107481a) a Pd-catalyzed protocol for conversion of an aryl triflate 1 to the halide 2.…
Organocatalyzed C-C Ring Construction: The Thomson Synthesis of Streptorubin
B Jinxing Ye of the East China University of Science and Technology used (Tetrahedron Lett. PMID:23399686 Formula of 240401-09-6 2011, 52, 2715. DOI: 10.1016/j.tetlet.2011.03.079) the Hayashi catalyst to direct the…
Enantioselective Preparation of Alcohols and Amines: The Lam Synthesis of (+)-Tanikolide
Takashi Ooi of Nagoya University effected (J. Am. Chem. PMID:23847952 Soc. 2010, 132, 12240. DOI: 10.1021/ja105945z) the enantioselective protonation of ketene silyl acetals such as 1 to give 2 in…
C-O Ring Construction: The Theodorakis Synthesis of (-)-Englerin A
Liming Zhang of the University of California, Santa Barbara described (J. Am. Chem. Soc. (R)-2-amino-1-phenylethan-1-ol manufacturer 2010, 132, 8550. DOI: 10.1021/ja1033952) the remarkable transformation of a propargyl alcohol 1 into…
Flow Methods for Organic Synthesis
Carrying out organic synthesis with a flow reactor can offer significant advantages over the more conventional batch processing. Andreas Kirschning of Leibniz Universität Hannover concisely summarized (Chem. Commun. 2011, 47,…