Alkyne Metathesis in Organic Synthesis
Chemexpress While alkyne metathesis is not going to displace alkene metathesis as a synthetic method, it is a complementary approach that can offer advantages. Catalysts for alkyne metathesis are still under…
Enantioselective α-Functionalization of Carbonyl Compounds
The enantioselective oxygenation procedures, epoxidation and dihydroxylation, developed by Barry Sharpless have dominated single-enantiomer organic synthesis. Recently, several additional methods for enantioselective oxidation have been developed, based on the α-functionalization…
Enantioselective Construction of
Arrays of Stereogenic Centers Single enantiomer synthesis is of increasing importance in pharmaceutical production. It is essential that practical and scalable procedures be developed for controlling the absolute configuration of…
Enantioselective Allylic Carbon-Carbon Bond Construction
Although many methods have been developed for enantioselective carbon-carbon construction, not all of these are robust and scalable. A promising recent addition has been the development of protocols for the…
Best Synthetic Methods
Benzyl ethers are among the most commonly used protecting groups for alcohols. PMID:23554582 Usually, these are prepared using an excess of NaH and benzyl bromide. Buy1-(Aminomethyl)cyclopentanol Okan Sirkecioglu of Istanbul…
Asymmetric Transformation of Prochiral Carbocyclic Rings
The push toward enantiomerically-purecarbocyclic intermediates has led to the development of new methods for the enantiodifferentiation of inexpensive prochiral cyclic starting materials. For instance, Robert H. Morris of the University…
Enantioselective Sulfoxidation
In the last few years, chiral sulfoxides have become important targets in organic synthesis, and their chemistry has recently been reviewed (Org. Chem. Highlights 2004, December 24. Link). An increasing…
Enantioselective Aza-Henry and Aza-Michael Reactions
The asymmetric conjugate addition is regarded as one of the most powerful tools for the selective formation of chiral C-C or C-X bonds. Particular cases of this methodology are the…
Hypervalent Iodine Chemistry
Weaker and longer than covalent linkages, hypervalent bonds are the result of a linear three-center, four-electron (3c-4e) electronic distribution (hypervalent model). PMID:23927631 Hypervalent iodine reagents are useful synthetic tools due…
Asymmetric Cross-Aldol Reactions Of Aldehydes: A Formidable Synthetic Challenge
The aldol addition reaction is one of the most versatile, effective and general methods for the formation of C-C bonds in modern organic synthesis. The challenge raised by nature has…