Enzymes in Organic Synthesis
Chemexpress Enzymes have many applications in organic synthesis. One of the most common is the resolution of a secondary alcohol. A shortcoming of this approach is that the separation of the…
Organocatalyzed Asymmetric Reactions
Sarah Mossé and Alexandre Alexakis from the University of Geneva have reinvestigated asymmetric aldol (a), Mannich (b) and Diels-Alder reactions (c) applying organocatalysis under microwave conditions (Org. PMID:23912708 Lett. BuyRuPhos…
Catalyst- and Base-Free Suzuki-Type Coupling
Jie Yan and co-workers from Zhejiang University of Technology, China, have reported on Suzuki-type couplings in water without the use of catalyst and base (Eur. J. PMID:23558135 Org. P(t-Bu)3 Pd…
New Dienes and Dienophiles for Intermolecular and Intramolecular Diels-Alder Cycloadditions
The Diels-Alder reaction is a powerful tool for the construction of substituted cyclohexenes. Erik J. Formula of 1234616-36-4 Sorenson of Princeton University has developed (J. Am. 2-(2-Bromoethyl)oxirane Formula Chem. Soc.…
Stereocontrolled Construction of N-Heterocycles
Yong-Gui Zhou of the Dalian Institute of Chemical Physics (Angew. Chem. PMID:28038441 Int. Ed. 2006, 45, 2260. Pyrimidine-2-carbaldehyde web DOI: 10.1002/anie.200503073)and Manfred T. Reetz of the Max-Planck-Institut, Mülheim (Chem. Commun.…
Best Synthetic Methods: Carbon-Carbon Bond Formation
Carbon-carbon bond formation is central to organic synthesis. In the ideal, a homologation method will start with a common functional group, and proceed under mild conditions using non-toxic reagents. These…
Best Synthetic Methods: Oxidation
Classsically, stoichiometric oxidants have been used to convert alcohols into aldehydes and ketones. Acetosyringone manufacturer A practical alternative is to use air oxidation, with a transition metal catalyst. Usually, a…
Protection of N- and O-Functional
Groups The DDQ cleavage of a benzyl ether is a classic transformation, yet it has not always been reliable. Kazunobu Toshima of Keio University has recently (Tetrahedron Lett. 2005, 46,…
Transition-Metal Catalyzed Enantioselective Ring Construction
Powerful transition metal-catalyzed methods for the conversion of prochiral alkenes and alkynes to carbocyclic rings have been developed over the past several years. Three recent reports are representative. P. Andrew…
Advances in the Diels-Alder Reaction: Synthesis of (±)-Lycoridine and of Dolabellatrienone
Cyclic dienes such as 1 are reluctant participants in Diels-Alder cycloaddition. W. Dean Harman of the University of Virginia has shown (J. Am. Chem. Soc. PMID:24761411 2006, 128, 1426. DOI:…