One-Pot Cyclization/Suzuki Coupling
Chemexpress Erin DiMauro and Joseph Kennedy from Amgen have developed a microwave protocol for the synthesis of a focused library of 3-amino-imidazopyridines 3 (J. Org. Chem. 2007, 72, 1013. DOI: 10.1021/jo0622072).…
Synthesis of Polysubstituted Aromatic Nitriles
The group of Mark Lautens from the University of Toronto has reported on the Pd-catalyzed C-H functionalization reaction for the synthesis of highly substituted benzonitriles (J. PMID:27017949 Am. 1-Phenylbuta-2,3-dien-1-one Purity…
His context, Idell et al. [37] showed that kallikrein, prekallikrein, and factor
His context, Idell et al. showed that kallikrein, prekallikrein, and issue XIa-like activities as well as the HK antigen were discovered in BALF of sufferers with ARDS (adult respiratory distress…
Slow progression of CDK. Renal diets are modified from upkeep diets
Slow progression of CDK. Renal diets are modified from upkeep diets in numerous strategies including supplementation with (n-3) polyunsaturated fatty acids plus the addition of antioxidants. A proinflammatory eating plan,…
Ketone Reduction via Transfer Hydrogenation
The group of Hans Adolfsson from Stockholm University has shown that ketones can be reduced to the corresponding alcohols via transfer hydrogenation in the absence of a transition metal catalyst…
Synthesis of Pyrido[2,3-d]pyrimidine-dione Derivatives
The group of Shujiang Tu from Xuzhou Normal University, China, has reported on the synthesis of a series of pyridopyrimidine-4,7-diones (Org. Biomol. Chem. 87789-35-3 In stock 2007, 7, ASAP.DOI: 10.1039/b617201f).…
Oxidation and Reduction in Organic Synthesis
The enantioselective reduction of ketones byalcohol dehydrogenases is a valuable synthetic procedure, but the required co-factors are expensive. If the reduction can be carried out with intact cells, the expense…
The Intramolecular Diels-Alder Reaction in Natural Product Synthesis
A key step in the Gin synthesis of the hetesine alkaloid nominine reviewed last week ( 2007, August 6) was an intramolecular Diels-Alder reaction. There have been several other recent…
Stereoselective C-N Ring Construction
Several new methods for C-N ring construction based on enantioselective addition to imines have been reported. Michael J. Krische of University of Texas at Austin has used (J. Am. Chem.…
Selective Reactions of Alkenes
Peter W. Roesky of the Freie Universität Berlin has devised (Chem. Commun. 2006, 874. DOI: 10.1039/b514242c)a La catalyst that effects hydrosilylation of a terminal alkene 1 to 2. Sjoerd Harder…