The polyene macrolide RK-397 (3), isolated from soil bacteria, has antifungal, antibacterial and anti-tumor activity. Tarek Sammakia of the University of Colorado has described (Angew. 1-Acetoxy-1,2-benziodoxol-3-(1H)-one site Chem. PMID:23546012 Int.…
The pentacyclic alkaloid (+)-lyconadin A (3), isolated from the club moss Lycopodium complanatum, showed modest in vitro cytotoxicity. A key step in the first reported (J. PMID:23805407 Am. Chem. Soc.…
The monoterpene alkaloid (-)-incarvillateine (3) has interesting symmetry properties. The centralcyclobutane diacid core is not itself chiral, but the appended alkaloids are. The key step in the total synthesis of…
The macrolactone leucascandrolide A (4), isolated from the calcareous sponge L. caveolata, has both cytotoxic and antifungal activity. The key step in the synthesis of 4 reported (J. Org. Chem.…
Rapamycin (3) is used clinically as an immunosuppressive agent. The synthesis of 3 (Angew. N-(2-Hydroxyethyl)maleimide Data Sheet Chem. Int. PMID:35345980 Morpholin-2-one site Ed. 2007, 46, 591.DOI: 10.1002/anie.200604053)by Steven V. Ley…
Cruentaren A (3), isolated from the myxobacterium Byssovorax cruenta, is an inhibitor of mitochondrial F-ATPase. The synthesis of 3 (Org. Lett. 2007, 9, 655, DOI: 10.1021/ol0629317; Angew. Chem. Int. Ed.…
(+)-Superstolide A (3), isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at ~ 4 ng/mL concentration. The key transformation in the synthesis of…
Ome 22 (nucleotide 17,049,3907,056,254, 6,865 bp, GEO accession quantity for the aCGH is GEO: GSE89191; Supplementary Information). These cytogenetic observations helped interpret quantitative measurements of codon 707 mutations by dPCR.…
Es (, , and MSH) are a loved ones of peptide hormones that regulate skin pigment cells and impact a array of other processes within the physique, including decreasing inflammation…
A recent publication by the group of Phil S. Baran from the Scripps Research Institute (Angew. Formula of 3-Vinylthiophene Chem. Int. Ed. PMID:24268253 2004, 43, 2674. DOI: 10.1002/anie.200453937) reports the…
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