Huanfeng Jiang of the South China University of Technology showed (J. Org. 5-Bromo-2-(tert-butyl)pyridine Purity Chem. 2010, 75, 966. DOI: 10.1021/jo902375k) that an alkynoate 1 could be condensed with a 1,3-dicarbonyl…
Lee), (-)-Amphidinolide K (Eun Lee), Norhalichondrin B (Phillips) A variety of antibiotics and immune-suppressive agents contain extended arrays of all-(E)-polyenes. Samir Bouzbouz of CNS Rouen and Janine Cossy of ESPCI…
Ng oestrogen and progesterone receptors and HER-2 gene amplification, account for ten?0 of all breast carcinomas in Asian and Western populations (Thike et al, 2010; De Ruijter et al, 2011).…
For synthesis of higher polyamines, putrescine controls the self-processing conversion of SAM decarboxylase (AMD1) proenzyme for the active enzyme (Pegg, 2009). Moreover, putrescine can bind an allosteric site in AMD1…
Vinyl glycine 2 is a useful precursor to a variety of amino acids. PMID:23789847 Timothy E. Long of the University of Georgia found (Tetrahedron Lett. 2009, 50, 5067. DOI: 10.1016/j.tetlet.2009.06.082)…
(+)-Rotundial Karl Anker Jørgensen of Aarhus University found (Angew. Chem. Int. 1075198-30-9 Formula Ed. 2009, 48, 6650. DOI: 10.1002/ange.200903253) that an organocatalyst could mediate the fragmentation of the prochiral cyclopropane…
Keiji Maruoka of Kyoto University found (Org. 8-Bromoquinazoline-2,4-diol Purity Lett. 2010, 12, 1668. DOI: 10.1021/ol100104v) that the diazo amide 1 derived from the Oppolzer sultam condensed with the imine 2…
Masato Kitamura of Nagoya University investigated (Chem. Lett. 2009, 38, 188. DOI: 10.1246/cl.2009.188) the Ru-mediated deprotection of allyl ethers such as 1. The same catalyst was effective for the preparation…
Varinder K. Aggarwal of the University of Bristol showed(Angew. Chem. Int. Ed. 2009, 48, 1149.DOI: 10.1002/anie.200805272)that condensation of a boronic ester 2 with a metalatedaziridine 1 led, after oxidation, to…
Enantioselective target-directed synthesis, which is important both for single-enantiomer pharmaceuticals and for natural product total synthesis, depends on the ability to form carbon-carbon bonds with absolute stereocontrol. Ethyl 4-methyl-1H-pyrrole-2-carboxylate Formula…
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