{Development|Improvement} of sustainable oxidation chemistrydemands {strategies|methods|techniques|approaches|tactics} to harness O2 as a terminal oxidant. Inparticular, oxidasecatalysis, in which O2 serves as a chemical oxidant withoutnecessitating oxygen incorporation into reaction {products|goods|items|merchandise|solutions}, would {allow|permit|enable|let} diversesubstrate functionalization chemistry {to be|to become} coupled to O2 reduction.Direct O2 utilization {must|should|need to|have to|ought to|will have to} overcomethe intrinsic challenges imposed by the triplet ground state of O2 andthe disparate electron inventories of four-electron O2 reduction andtwo-electron substrate oxidation. {Here|Right here}, we {generate|produce|create} hypervalent iodinereagents, a broadly {useful|helpful|beneficial|valuable} class of selective two-electron oxidants, from O2.Synthesis {of these|of those} oxidants is {achieved|accomplished} by intercepting reactive intermediatesof aldehyde autoxidation. {The use of|The usage of} aryl iodides as mediators of aerobicoxidation underpins an oxidase catalysis platform that couples a broad array ofsubstrate oxidations to O2 reduction, {including|such as|which includes|like} olefinfunctionalization chemistry, carbonyl a-oxidation, oxidative dearomatization, andaerobic C–H amination chemistry. Mal-PEG4-OH Price Formula of 4-Chloro-5-cyano-7-azaindole PMID:23329650