Phagy inhibition. Autophagy is upregulated in response to erlotinib in NSCLC cell lines and combined therapy with chloroquine, an antimalarial that inhibits autophagy, enhances erlotinib sensitivity (Li, Lam, Mak, Zheng,…
Ere processed in parallel. A few sections wereAuthor Manuscript Author Manuscript Author Manuscript Author ManuscriptMol Neurobiol. Author manuscript; obtainable in PMC 2017 July 20.Sharma et al.Pagecounterstained with Haematoxylin-Eosin for great…
John Verkade and Steven Raders from Iowa State University have reported on the synthesis of diaryl ethers by the reaction of electron deficient aryl fluorides with variousTBDMS-protected phenols (Tetrahedron Lett.…
In the chemistry described below, Coats and a group of researchers from Johnson and Johnson utilized successive reductive aminations and Suzuki cross coupling reactions to prepare a 192-member library of…
The group of Stefan Bräse from the University of Karlsruhe has performed optimization studies toward solvent, time, temperature and catalyst loading for the microwave-mediated organocatalytic asymmetric α-amination of disubstituted aldehydes…
A small library of 2,4(1H,3H)-quinazolinediones (X = O) and 2-thioxoquinazolines (X = S) was prepared via the reaction of substituted methyl anthranilate with diverse iso(thio)cyanates without the addition of catalyst,…
John Walton and co-workers from the University of St. Andrews, UK, have reported on the use of O-phenyl oxime ethers as precursors for iminyl radicals en route for N-heterocycle synthesis…
The synthesis of 1,2,3-triazoles via Ru-catalyzed aryl azide-alkyne cycloadditions was described by the group of Valery Fokin from The Scripps Research Institute (Org. Lett. 2007, 9, 5337. DOI: 10.1021/ol701912s). PMID:35991869…
The intramolecular cycloaddition of alkenyl- (1) and aryl-substitued 1,6-enynes 2 was described by the group of Antonio Echavarren from the Institute of Chemical Research of Catalonia (ICIQ), Spain, (J. PMID:25046520…
Chemexpress