Enantioselective Sulfoxidation
Chemexpress In the last few years, chiral sulfoxides have become important targets in organic synthesis, and their chemistry has recently been reviewed (Org. Chem. Highlights 2004, December 24. Link). An increasing…
Enantioselective Aza-Henry and Aza-Michael Reactions
The asymmetric conjugate addition is regarded as one of the most powerful tools for the selective formation of chiral C-C or C-X bonds. Particular cases of this methodology are the…
Hypervalent Iodine Chemistry
Weaker and longer than covalent linkages, hypervalent bonds are the result of a linear three-center, four-electron (3c-4e) electronic distribution (hypervalent model). PMID:23927631 Hypervalent iodine reagents are useful synthetic tools due…
Asymmetric Cross-Aldol Reactions Of Aldehydes: A Formidable Synthetic Challenge
The aldol addition reaction is one of the most versatile, effective and general methods for the formation of C-C bonds in modern organic synthesis. The challenge raised by nature has…
Enantioselective Construction of Aminated Secondary Stereocenters
The enantioselective construction of aminated stereogenic centers is a central task both for pharmaceutical production and for alkaloid synthesis. Activated aziridines should be as useful as epoxides for carbon-carbon bond…
Organic Synthesis in Water
Water plays an essential role in life processes, however its use as a solvent has been limited in organic synthesis. Despite the fact that it is the cheapest, safest and…
Boranes in Cancer Therapy
The use of boranes in a promising experimental approach to cancer treatment is one of the most challenging current targets of medicinal chemistry. Fmoc-8-amino-3,6-dioxaoctanoic acid web Amine-carboxyboranes Amine-carboxyboranes (A•BH2COOH) are…
Hanced Kir6.2 signal at the cell periphery, but this leptin effect
Hanced Kir6.two signal in the cell periphery, but this leptin impact was significantly inhibited by CC (Fig. 2E). For quantitative analysis, the ratio of peripheral to total Kir6.2 signal was…
Uncommon genetic variations, contributed for the divergent HERV responses and variable
Uncommon genetic variations, contributed for the divergent HERV responses and variable responses to injury. Particularly, patientspecific genomic HERVs may perhaps play a role, at least in aspect, inside the variable…
Thor ManuscriptTurning towards the second question, the correlation in between folding prices
Thor ManuscriptTurning towards the second question, the correlation amongst folding prices and thermodynamic stability, this has been studied extensively in other systems, specifically proteins. A typical feature observed in prior…