Christopher Uyeda of Purdue University achieved high enantioselectivity in the cyclopropanation of myrcene (1) with 2,2-dichloropropane (2) to give 3 (J. Am. Chem. Soc. 2023, 145, 9441. DOI: 10.1021/jacs.3c01949). Qinglei…
Vicente Gotor-Fernández and Iván Lavandera of the Universidad de Oviedo optimized the enzymatic reduction of the chloroketone 1 to the chlorohydrin 2, then telescoped that to begin with the 1-chloroalkyne…
Malte Brasholz of the University of Rostock developed a protocol for the photochemically-driven in situ oxidation of the quinoxalinone 1 followed by cycloaddition with methacrylonitrile 2 to give the azetidine…
two.five L) and terminal TdT (25 Units) in buffer (Promega, Madison, WI). Cellspecific immunohistochemical labeling was performed as previously described (Guyton et al. 2009). Briefly, before primary antibody staining, nonspecific…
The logistic regression evaluation revealed that being an injection drug user (IDU) was substantially related to HCV infection. Having said that, contrary to the majority of the existing literature, getting…
Haibo Ge of Texas Tech University and Debabrata Maity of the Indian Institute of Technology Bombay effected the m-acetoxylation of the ester 1, leading to 2 (JACS Au 2023, 3,…
Arjan W. Kleij of ICIQ optimized an aluminum catalyst for the conversion of the bis epoxide 1 to the oxetane 2 (ACS Catal. PMID:23399686 2022, 12, 5464. DOI: 10.1021/acscatal.2c00925). A.…
Mark G. 259214-55-6 uses McLaughlin of the University of Lancaster found that under alkaline conditions, the alcohol 1 could be cyclized to the iodo oxetane 2 (Chem. Commun. 2022, 58,…
The ginkgolides, in particular ginkgolide B, lacking the OH at C-7, are potent antagonists of platelet-aggregating acceptor (PAFR). PMID:24275718 Louis Barriault of the University of Ottawa described the first synthesis…
The tetraketone aberrarone (3), isolated from the feathery Caribbean gorgonian Pseudopterogorgia elisabethae, shows in vitro activity against the malaria parasite. Yanxing Jia of Peking University devised a route to 3…
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